Piroxicam – Essential Info for Patients and Clinicians

When you come across Piroxicam, a non‑steroidal anti‑inflammatory drug (NSAID) used to relieve pain and swelling in conditions like arthritis. Also known as Feldene, it works by blocking enzymes that produce inflammatory chemicals.

Piroxicam belongs to the broader class of NSAIDs, drugs that reduce fever, pain and inflammation by inhibiting cyclooxygenase enzymes. These enzymes, COX‑1 and COX‑2, are the same targets that aspirin and ibuprofen hit. Because NSAIDs share this mechanism, they also share common safety considerations, especially for the stomach and kidneys.

Most people search for Piroxicam when they have arthritis, a group of joint diseases marked by pain, stiffness and reduced mobility. Whether it's osteoarthritis from wear‑and‑tear or rheumatoid arthritis driven by an autoimmune flare, Piroxicam can ease the aching and improve daily function. It’s often chosen when doctors need a longer‑acting option than ibuprofen but don’t want to jump to stronger prescription steroids.

One of the biggest warnings with Piroxicam is its impact on the gastrointestinal tract, the stomach and intestines where NSAIDs can cause irritation, ulcers or bleeding. The risk grows if you’re over 60, drink alcohol, or take other ulcer‑promoting meds. Monitoring for signs like black stools, abdominal pain or unexplained fatigue can catch problems early. Sometimes doctors add a proton‑pump inhibitor to protect the lining while you stay on the anti‑inflammatory.

What to watch for when using Piroxicam

Besides gut issues, Piroxicam can affect kidney function, especially in people with dehydration or pre‑existing kidney disease. It’s also less selective for COX‑2, so the heart‑related risks that newer COX‑2‑selective drugs aim to lower may still apply. If you have a history of heart disease, discuss alternatives or dose adjustments with your clinician. Dosage forms vary—there are oral tablets, topical gels, and even ophthalmic drops for eye inflammation. Choose the form that matches the target area and your tolerance for systemic side effects.

All of these pieces—drug class, condition treated, side‑effect profile, and formulation—create a clear picture of when Piroxicam makes sense and when you might need a different route. Below you’ll find a curated collection of articles that dive deeper into drug interactions, safety checks, and practical tips for managing common conditions with Piroxicam and related medicines. Keep reading to get the details you need for safe, effective use.