Action And Clinical Pharmacology: Amoxicillin exerts a bactericidal action against sensitive organisms during the stage of active multiplication through the inhibition of the biosynthesis of bacterial cell wall mucopeptides. Clavulanic acid inhibits specific b-lactamases of some microorganisms and allows amoxicillin to inhibit amoxicillin (ampicillin) resistant organisms which produce clavulanic acid sensitive b-lactamases. tag_IndicationsIndications Indications And Clinical Uses: For the treatment of the following infections when caused by Clavulin-susceptible strains of the designated bacteria: Upper respiratory tract infections when caused by b-lactamase producing strains of S. aureus. Sinusitis when caused by b-lactamase producing strains of H. influenzae or M. (B.) catarrhalis. Otitis media when caused by b-lactamase producing strains of H. influenzae or M. (B.) catarrhalis. Lower respiratory tract infections when caused by b-lactamase producing strains of H. influenzae, K. pneumoniae, S. aureus or M. (B.) catarrhalis. Skin and soft tissue infections when caused by b-lactamase producing strains of S. aureus. Urinary tract infections when caused by b-lactamase producing strains of E. coli, P. mirabilis or Klebsiella species. While Clavulin is indicated only for the conditions listed above, infections caused by ampicillin (amoxicillin) susceptible organisms are also amenable to Clavulin treatment due to its amoxicillin content. Furthermore, mixed infections caused by organisms susceptible to ampicillin (amoxicillin) and b-lactamase producing organisms susceptible to Clavulin should not require the addition of another antibiotic. Appropriate culture and susceptibility studies should be performed to identify the causative organism(s) and determine the susceptibility to Clavulin. However, when there is reason to believe an infection may involve any of the b-lactamase producing organisms listed above, therapy may be instituted prior to obtaining the results from bacteriological and susceptibility studies. Once these results are known, therapy should be adjusted if appropriate. Contra-Indications: In patients with a history of hypersensitivity to the penicillin, clavam, or cephalosporin group of b-lactams. In patients where infectious mononucleosis is either suspected or confirmed. In patients with a previous history of Clavulin-associated jaundice/hepatic dysfunction.