BRAND NAME: Anaprox, Naprelan, Naprosyn, Aleve DRUG CLASS AND MECHANISM: Naproxen belongs to a class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs). Other members of this class include ibuprofen (Motrin), indomethacin (Indocin), nabumetone (Relafen) and several others. These drugs are used for the management of mild to moderate pain, fever, and inflammation. They work by reducing the levels of prostaglandins, chemicals that are responsible for pain, fever and inflammation. Naproxen blocks the enzyme that makes prostaglandins (cyclooxygenase ), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced. Naproxen was approved by the FDA in December, 1991. PRESCRIBED FOR: Naproxen is used for the treatment of mild to moderate pain, inflammation and fever. DOSING: The usual adult dose is 250-500 mg twice daily using regular naproxen tablets. The usual dose for Naprelan controlled release tablets is 750 to 1000 mg given once daily. For EC-Naprosyn, the usual dose is 375-500 mg twice daily. Naproxen should be given with food to reduce upset stomach. DRUG INTERACTIONS: Naproxen is associated with several suspected or probable interactions that affect the action of other drugs. The following examples are the most common suspected interactions. Naproxen may increase the blood levels of lithium (Eskalith) by reducing the excretion of lithium by the kidneys. Increased levels of lithium may lead to lithium toxicity. Naproxen may reduce the blood pressure lowering effects of blood pressure medications. This may occur because prostaglandins play a role in the regulation of blood pressure. When naproxen is used in combination with aminoglycosides (e.g., gentamicin) the blood levels of the aminoglycoside may increase, presumably because the elimination of aminoglycosides from the body is reduced. This may lead to more aminoglycoside-related side effects. Individuals taking oral blood thinners or anticoagulants (e.g., warfarin) should avoid naproxen because naproxen also thins the blood, and excessive blood thinning may lead to bleeding. PREGNANCY: There are no adequate studies of naproxen in pregnant women. Therefore, naproxen is not recommended during pregnancy.