Ketoprofen is used to reduce pain, swelling, and joint stiffness from arthritis. It is also used to relieve mild to moderate pain such as menstrual cramps, headaches, muscle aches, backaches, and dental pain. In addition, ketoprofen is used to reduce fever and to relieve minor aches and pains due to the common cold or flu. This medication is known as a nonsteroidal anti-inflammatory drug (NSAID). How to use Ketoprofen Oral Read the Medication Guide provided by your pharmacist before you start using ketoprofen and each time you get a refill. If you have any questions regarding the information, consult your doctor or pharmacist. Take this medication by mouth with a full glass of water (8 ounces or 240 milliliters), unless your doctor directs you otherwise. Do not lie down for at least 30 minutes after taking this drug. If stomach upset occurs while taking this medication, take it with food, milk, or an antacid. The dosage is based on your medical condition and response to therapy. Do not increase your dose or take it more frequently than recommended because this may increase your risk of stomach bleeding. Do not take more than 100 mg daily if you have severe kidney disease. The smallest effective dose should be used. Consult your doctor or pharmacist for more information. If you are using this medication to relieve arthritis, take it usually 3 or 4 times a day on a regular schedule, or as directed by your doctor. If you are using ketoprofen on an "as needed" basis (not on a regular schedule), remember that pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has significantly worsened, the medicine may not work as well. If repeat doses are needed, they can be taken usually 6 or 8 hours apart, or as directed by your doctor. If you use this medication for migraine headache, and the pain is not relieved or worsens after the first dose, tell your doctor immediately. For nonprescription ketoprofen products: Follow the package instructions. Consult your doctor before taking this medication if the painful area is red or swollen. Consult your doctor immediately if fever or pain do not improve within 24 hours, worsen or last for more than 3 days, or if new symptoms appear. In general, do not take more than 2 tablets (25 milligrams) in a 4-6 hour period or 6 tablets (75 milligrams) in a 24 hour period. Do not use in children less than 16 years old unless so directed by the doctor. In certain conditions (e.g., arthritis), it may take up to 2-4 weeks, taken regularly, before the full benefits of this drug take effect. Inform your doctor if your condition persists or worsens.