Aciphex Oral Uses Rabeprazole works by blocking acid production in the stomach. This medication is known as a proton pump inhibitor (PPI). It is used to treat acid-related stomach/intestinal and throat (esophagus) problems (e.g., acid reflux or GERD, ulcers, erosive esophagitis, Zollinger-Ellison syndrome). Decreasing excess stomach acid can help relieve symptoms such as heartburn, difficulty swallowing, persistent cough, and trouble sleeping. It can also prevent serious acid damage to your digestive system (e.g., ulcers, cancer of the esophagus). This medication may also be used in combination with antibiotics to treat certain types of ulcers caused by bacterial infection. How to use Aciphex Oral Take this medication by mouth usually once daily, with or without food, or as directed by your doctor. Do not crush, chew, or split this medication. Swallow the medication whole. If needed, antacids may be taken along with this medication. The dosage and length of treatment is based on your medical condition and response to therapy. Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time each day. Continue to take this medication for the prescribed length of treatment even if you are feeling better. Inform your doctor if your condition persists or worsens.