Is clomiphene for you? Clomiphene can help you conceive if you ovulate irregularly or not at all, particularly if you have polycystic ovarian syndrome (PCOS). (If you have PCOS and this treatment doesn't seem to work for you, your doctor may also prescribe metformin, an insulin-sensitizing drug that can help you respond to clomiphene.) You might also take clomiphene (and other fertility drugs) before you undergo an assisted reproductive technology (ART) treatment such as in vitro fertilization (IVF), to encourage you to produce several eggs for the procedure. Clomiphene can also help men with a hormonal imbalance (that originates in the pituitary gland or hypothalamus) linked to a low sperm count, or poor sperm quality or motility (its ability to move). (For more information about fertility drugs for men, click here.) Treatment: What to expect Clomiphene is usually taken in pill form for one five-day cycle a month. It helps you produce more of the hormones that trigger ovulation (follicle-stimulating hormones (FSH)), prompting your ovaries to produce one or more mature eggs, depending on how often you normally ovulate. After you finish a cycle of clomiphene, your hypothalamus (the part of your brain that regulates basic functions such as temperature) releases luteinizing hormone (LH), which tells your ovaries to release your mature egg or eggs into your fallopian tubes. If an egg meets up with a healthy sperm on it then you got it!.