Generic Name: leflunomide (oral) (leh FLEW no mide) Brand Names: Arava What is the most important information I should know about leflunomide? • Leflunomide is in the FDA pregnancy category X. There is an increased risk of birth defects and death of the unborn baby while taking leflunomide. Do not take this medication if you are pregnant or could become pregnant during treatment. Notify your doctor immediately if you think you have become pregnant during treatment. Birth control must be used during treatment with leflunomide. Discuss with your doctor the procedure for removing leflunomide from the body following treatment before becoming pregnant. Without the proper drug elimination procedure, it may take up to two years before leflunomide is at sufficiently low levels in the body so as to reduce the risk of harm to an unborn baby. It is not known whether leflunomide imposes an increased risk of fetal harm when taken by a man. Men wishing to father a child while taking leflunomide should discuss their options with their doctor. What is leflunomide? • Leflunomide affects the immune system and decreases inflammation. • Leflunomide is used to reduce the signs and symptoms of rheumatoid arthritis, reduce damage to the joints caused by rheumatoid arthritis, and to improve physical function in people with rheumatoid arthritis. • Leflunomide may also be used for purposes other than those listed in this medication guide.